RETRACTED ARTICLE: NEAT1 regulates Th2 cell development by targeting STAT6 for degradation
نویسندگان
چکیده
منابع مشابه
Grail controls Th2 cell development by targeting STAT6 for degradation
T helper (Th)-2 cells are the major players in allergic asthma; however, the mechanisms that control Th2-mediated inflammation are poorly understood. Here we find that enhanced expression of Grail, an E3 ubiquitin ligase, in Th2 cells depends on interleukin (IL)-4-signalling components, signal transducer and activator of transcription 6 (Stat6) and Gata3, that bind to and transactivate the Grai...
متن کاملThe Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation
Cell cycle progression is controlled by a complex regulatory network consisting of interacting positive and negative factors. In humans, the positive regulator Skp2, an F-box protein, has been a subject of intense investigation in part because of its oncogenic activity. By contrast, the molecular and developmental functions of its Drosophila homologue, dSkp2, are poorly understood. Here we inve...
متن کاملRbm46 regulates mouse embryonic stem cell differentiation by targeting β-Catenin mRNA for degradation
Embryonic stem cells (ESCs) are pluripotent cells and have the capability for differentiation into any of the three embryonic germ layers. The Wnt/β-Catenin pathway has been shown to play an essential role in ESC differentiation regulation. Activation of β-Catenin by post-translational modification has been extensively studied. However, mechanism(s) of post-transcriptional regulation of β-Caten...
متن کاملTargeting STAT6 in PMBL
Primary Mediastinal B-cell Lymphoma (PMBL) is a specific subtype of B-cell lymphoma which shares some phenotypic and genotypic features with diffuse large B-cell lymphoma (DLBCL) and with classical Hodgkin’s lymphoma (HL). The genomic landscape of PMBL has not been fully elucidated, but has revealed the recurrent alteration of genes involved in JAK-STAT signaling and in immune surveillance [1]....
متن کاملFbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation
BACKGROUND The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear. METHODS We evaluated Fbw7 expression in patient samples of DLBCL using immunohistochemical staining. The effect of Fbw7 overexpression on cell viability and apoptosis was invest...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2019
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2018.1562285